Research Topic in General:

Pharmacogenomic, Drug Repurposing, Genomic Variation Stud

Current Research Interests:

*Pharmacogenomic in Liver Disease

*Pharmacogenomic and Precision Medicine in Liver Disease (Hepatocellular Carcinoma), Hepatitis B and Chronic Hepatitis B

*In Sillico/Bioinformatic for Drug Discovery and Drug Repositioning for Liver Disease (Hepatocellular Carcinoma) and Colorectal Cancer

*Genome Wide Association Study (GWAS) for Liver Disease (Hepatocellular Carcinoma), Genomic for COVID-19/SARS-COV2.

*Identification of Genomic variation (Single Nucleotide Polymorphisms/SNPs) and function in human health and disease.

Representative Publications:

Nidaul Makwa, Dyah Aryani Perwitasari*, Imaniar Noor Faridah, Lalu Muhammad Irham, Haafizah Dania, Rita Maliza. Published in Advances in Health Sciences Research, volume 33,16 January 2021. Variation of CYP2C9 Gene and Glycemic Control in Diabetic Patients: A Literature Review.

Dyah Aryani Perwitasari, Imaniar Noor Faridah, Haafizah Dania, Lolita, Lalu Muhammad Irham, Muthia Dewi Marthilia Alim, Maratun Shoaliha, Mochammad Junaidy Heriyanto. Journal of Education and Health Promotion. December 2020 (Accepted). The knowledge of COVID-19 treatments, behaviors, and attitudes of providing the information on COVID-19 treatments: Perspectives of pharmacy students

Dyah Aryani Perwitasari, Imaniar Noor Faridah, Haafizah Dania, Lalu Muhammad Irham, Fathia Vikri Salsabila, Rita Maliza. Genotype of Potassium Inwardly Rectifying Channel, Subfamily J, Member 11 (KCNJ 11) Gene and Glycaemia Control in Diabetic Patients: A Narrative Review. (Published in Systematic Reviews in Pharmacy). 2020; 11(9): 627-631. doi: 10.31838/srp.2020.9.92.

Lalu Muhammad Irham, Wan-Hsuan Chou, Yu-Shiuan Wang, Wirawan Adikusuma, Henry Sung-Ching Wong, Dyah Aryani Perwitasari, Wan Chen Huang, Ben Kuen Chen *, Hwai I Yang *, Wei Chiao Chang *. Evaluation for the Genetic Association Between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection. (Published in Biology Journal MDPI 11/09/2020) and Covered by the Science Citation Index Expanded (SCIE) in Web of Science. Biology. 2020; 9(11):388. Impact factor (IF): 3.796 (2019); SCIE ranking:20.4%~19/93 (Q1); SCImago Journal Rank (SJR);1.74.

Lalu Muhammad Irham#, Wan-Hsuan Chou#, Marcus J. Calkins, Wirawan Adikusuma, Shie-Liang Hsieh, Wei-Chiao Chang*. Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents. (Published in Biochemical and Biophysical Research Communication) and Covered by the Science Citation Index Expanded (SCIE) in Web of Science. doi: 10.1016/j.bbrc.2020.08.20. 179. Epub 2020 Jun 8. PMID: 32703421. Impact factor (IF): 2.985 (2019); SCIE ranking: 53.5%~159/297 (Q2); SCImago Journal Rank (SJR);0.966.

Bayu Tri Murti, Athika Darumas Putri, Lalu Muhammad Irham, Dyah Aryani Perwitasari, Chien-Ming Hsieh, Po-Kang Yang, Suvaradhan Kanchi, Myalowenkosi Sabela. Book Chapter edition” Current trends, achievements and prospects of smart nanodevices in global pharma market~Nanomaterials in Diagnostic Tools and Device”. Published at 5th June 2020 (ISBN:9780128179239) Elsevier 2020 (Scopus)

Lalu Muhammad Irham, Henry Sung-Ching Wong, Dyah Aryani Perwitasari, Wan-Hsuan Chou, Hwai-I Yang*, Wei-Chiao Chang*. Single-Nucleotide Polymorphism of rs7944135 (MPEG1) is Associated with Hepatitis B Surface Antigen (HBsAg) Seroclearance in Chronic Hepatitis B Infection: A cohort study. Medicine Journal Covered by the Science Citation Index Expanded (SCIE) in Web of Science. Medicine: December 2019 – Volume 98 – Issue 51 – p e17936. doi: 10.1097/MD.0000000000017936. Impact factor (IF): 1.998 (2019); SCIE ranking: 53.9%~89/165 (Q2); SCImago Journal Rank (SJR);0.64.

Dyah Aryani Perwitasari, Lalu Muhammad Irham, Endang Darmawan, Ully A Mulyani, J Atthobari. CYP2E1 polymorphism, acetylator profiles and drug-induced liver injury incidence of Indonesian tuberculosis patients, Indian Journal of Tuberculosis, (IJTB) 63(3), 139-143.

Lalu Muhammad Irham, Wahyu Widyaningsing, Aktifitas Hepatoprotektif Ekstrak Etanol Daun Sidaguri (Sida rhombifolia l.) Dilihat dari Rasio Berat Hepar, Nilai SGPT-SGOT, dan Histopatologi Hepar pada Tikus Sprague Dawley yang diinduksi CCL4, Media Farmasi 14, (1)61-76~01/2014. v14i1.9826

Lalu Muhammad Irham, Henry Sung-Ching Wong, Wan-Hsuan Chou, Wirawan Adikusuma, Eko Mugiyanto, Wan-Chen Huang*, Wei-Chiao Chang*. Integration of Genetic Variants and Gene Network for Drug Repurposing in Colorectal Cancer. (Published in Pharmacological Research) and Covered by the Science Citation Index Expanded (SCIE) in Web of Science. 2020 Sep 17:105203. doi: 10.1016/j.phrs.2020.105203. Epub ahead of print. PMID: 32950641. Impact factor (IF): 5.78 (2019); SCIE ranking: 7%~19/270 (Q1); SCImago Journal Rank (SJR);1.781

Selected Publications